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Heptelidic acid

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Heptelidic acid CAS 74310-84-2 SCBT - Santa Cruz ...

Heptelidic acid is a potent and selective GAPDH (glyceraldehyde 3-phosphate dehydrogenase) inhibitor. Suggested to act by binding to the essential Cys149 residue in the catalytic site of GADPH. Heptelidic acid is an apoptosis inhibitor that displays antibiotic, anticancer, and anitmalarial properties.


Heptelidic acid Antibiotic - MyBioSource

Small volumes of Heptelidic acid antibiotic vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap.


Heptelidic acid 74310-84-2

Visit ChemicalBook To find more Heptelidic acid(74310-84-2) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. You can also browse global suppliers,vendor,prices,Price,manufacturers of Heptelidic acid(74310-84-2).


Heptelidic acid (CAS 57710-57-3) - LS-H403

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.


Heptelidic acid C15H20O5 - PubChem

A chemical formula is a way of expressing information about the proportions of atoms that constitute a particular chemical compound, using a single line of chemical element symbols and numbers.


Heptelidic acid (Koningic acid) Abcam

Buy Heptelidic acid (Koningic acid) (CAS 74310-84-2), a potent GAPDH inhibitor and selective DNA polymerase inhibitor. Join researchers using high quality Heptelidic acid (Koningic acid) from Abcam


heptelidic acid (Concept Id: C0062557)

Heptelidic acid, a sesquiterpene lactone, inhibits Etoposide-induced apoptosis in human leukemia U937 cells.


A key step towards EPC synthesis of (+)-heptelidic acid ...

Absolute configuration of enoates 3n and 4n, which have been prepared as chiral building blocks for the EPC synthesis of the antibiotic (+)-heptelidic acid, was determined by X-ray structure analysis.


Heptelidic Acid CAS# 74310-84-2 2215 BioVision, Inc.

Heptelidic acid is a potent and selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GAPDH. Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP


Koningic acid - Wikipedia

Koningic acid (KA, also known as heptelidic acid) is a potent, selective, irreversible GAPDH inhibitor. It is also a DNA polymerase inhibitor. The koningic acid molecule, produced by fungi that consume sweet potatoes, has been shown to curb the excessive glucose consumption in tumors exhibiting the Warburg effect and leaving healthy cells alone.


SPECIFIC INHIBITION OF GLYCERALDEHYDE-3-PHOSPHATE ...

hexane from which koningic acid was obtained as crystals. Recrystallization was carried out in the same solution, yielding 2.6 g of white crystals of koningic acid. The isolated product was identified as heptelidic acid by comparing its molecular formula (C15H2005), and UV, IR, NMR and mass spectra


Phyto74n11 1346 - American Phytopathological Society

compound heptelidic acid (6), and the antifungal compound viridin (2). Viridiol, a compound with a molecular structure closely related to that of viridin, has also been reported from G. virens (8). In the course of studies on optimum inoculum production and application of G. virens to suppress cotton seedling disease, we


EPC synthesis of (+)-heptelidic acid Springer for ...

An EPC (enantiomerically pure compound) synthesis of the antibiotic natural product (+)-heptelidic acid (1) is presented. Key step of the synthesis is a conjugate addition of the acetal protected vinyl cuprate4 to the auxiliary shielded enoate5n which gives the adduct7n as a single diastereomer.


SAFETY DATA SHEET Page: 1 of 6 Heptelidic Acid Revision

Heptelidic Acid - Toxicity Data: Oral LD50 (mouse): >100 mg/kg; Intraperitoneal LD50 (mouse): 32 mg/kg; Information on Toxicological Effects: Heptelidic Acid - Investigated as a drug and natural product. Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here. See actual entry in RTECS for complete information.


TRC Details of CAS = 57710-57-3, ChemicalName ...

Heptalidic acid is a sesquiterpene lactone and found to inhibit etoposide-induced apoptosis in human leukemia U937 cells. In addition, it also inhibit mammalian DNA polymerases and terminal deoxynucleotidyl transferase.


Order BioVision's Heptelidic Acid SKU : 2215-1000 on ZAGENO

Heptelidic Acid SKU : 2215-1000s primary application is to interact with target reagents, but it may also be adjusted to fit corresponding scientific methods. Downstream Lab Experiments. After use, it may be necessary to carry out further experiments.


Heptelidic acid CAS 57710-57-3 - Order from Adipogen

Heptelidic acid (Koningic acid), CAS 57710-57-3 (74310-84-2 deleted), high purity chemical. Isolated from Penicillium sp. Antibiotic. Potent GAPDH inhibitor. Selectively kills high-glycolytic cancer cells. Antimalarial. Apoptosis inhibitor.


Heptelidic Acid, a Sesquiterpene Lactone, Inhibits ...

Furthermore, it was found that DNA fragmentation and caspase-3 activation, the biological hallmarks of apoptosis, were inhibited by the compound in a dose-dependent manner, suggesting that heptelidic acid inhibits etoposide-induced apoptosis via downregulation of caspases.


Koningic Acid - Cosmo Bio Co.,Ltd.

Koningic acid (CAS No. 57710-57-3) (Figure 1) is a sesquiterpene lactone (molecular mass of 280.3) produced by the fungus Trichoderma koningii (1). Koningic acid inhibits glyceraldehyde 3-phosphate dehydrogenase (GAPDH) from various species by binding to the essential Cys residue in the catalytic site through a thioether bond (2-4).


Heptelidic Acid - Creative Enzymes

A sesquiterpene antibiotic, isolated from Trichoderma sp. A potent and selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in


The X-ray crystal structure determination, and ...

A sesquiterpene lactone isolated from Gliocladium virens, was identical to the antibiotic, heptelidic acid The complete structure of heptelidic acid, including the orientation of the epoxide ring was determined by single crystal X-ray defraction analysis.


Heptelidic Acid, a Sesquiterpene Lactone, Inhibits ...

Heptelidic Acid, a Sesquiterpene Lactone, Inhibits Etoposide-Induced Apoptosis in Human Leukemia U937 Cells Kim, Jin-Hee; Lee, Choong-Hwan; Abstract In the course of screening for substances that inhibit etoposide (10 /ml)-induced apoptosis in human leukemia U937 cells, fungal strain F000120, which exhibits potent inhibitory activity, was selected.


Koningic acid (heptelidic acid) inhibition of ...

The sesquiterpene antibiotic koningic acid (heptelidic acid) has been previously demonstrated to modify glyceraldehyde-3-phosphate dehydrogenase in specific manner, probably by binding to the ...


Heptanoic acid - Wikipedia

Heptanoic acid, also called enanthic acid, is an organic compound composed of a seven-carbon chain terminating in a carboxylic acid. It is an oily liquid with an unpleasant, rancid odor. [1] It contributes to the odor of some rancid oils.


Substance Name: Heptelidic acid

57710-57-3 - JESMSCGUTIEROV-NOFREYILSA-N - Heptelidic acid - Similar structures search, synonyms, formulas, resource links, and other chemical information.


Total synthesis of (.+-.)-heptelidic acid Request PDF

According to Arigoni (1975), who investigated the biosynthesis of heptelidic acid, this compound was originally isolated from the ascomycete Anthostoma avocetta at Sandoz Pharmaceuticals (Sandoz ...


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